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JoVE Journal Neuroscience
A Simple Approach to Induce Experimental Autoimmune Neuritis in C57BL/6 Mice for Functional and Neuropathological Assessments
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A Simple Approach to Induce Experimental Autoimmune Neuritis in C57BL/6 Mice for Functional and Neuropathological Assessments

Article DOI: 10.3791/56455-v • 07:30 min • November 9th, 2017
November 9th, 2017 •
1, 1, 1, 1, 1, 1
1Department of Anatomy and Neuroscience, School of Biomedical Sciences, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne

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Summary
Automatic Translation

This report outlines a simple approach to successfully induce experimental autoimmune neuritis (EAN) using the myelin protein zero (P0)180-199 peptide in combination with Freund's complete adjuvant and pertussis toxin. We present a sophisticated paradigm capable of accurately assessing the extent of functional deficits and neuropathology that occur in this EAN.

Tags

Experimental Autoimmune Neuritis EAN Induction Mouse Model Functional Assessment Neuropathological Assessment Peripheral Neuropathy Therapeutic Agents Functional Testing Paradigm Motor Function Assessment Apparatus Gait Function Imaging System Treadmill Speed
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