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Un enzima Split-TET2 ingegnerizzati per chimica-inducible DNA Hydroxymethylation e rimodellamento epigenetico
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Un enzima Split-TET2 ingegnerizzati per chimica-inducible DNA Hydroxymethylation e rimodellamento epigenetico

Article DOI: 10.3791/56858-v • 08:34 min • December 18th, 2017
December 18th, 2017 •
1, 2, 1
1Centre for Epigenetics and Disease Prevention, Department of Molecular and Cellular Medicine, Institute of Biosciences and Technology, College of Medicine, Texas A&M University, 2Centre for Translational Cancer Research, Department of Medical Physiology, Institute of Biosciences and Technology, College of Medicine, Texas A&M University

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Protocolli dettagliati per l'introduzione di un enzima derivati dal Spalato-TET2 (sidro) nelle cellule di mammiferi per chimica viscoelastica DNA hydroxymethylation e rimodellamento epigenetici sono presentati.

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Chimica problema 130 metilazione del DNA epigenetica all'accessibilità cromatinica demetilazione del DNA biologia chimica TET2 5-idrossimetilcitosina trascrizione espressione genica epigenome editing
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