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Journal / Cancer Research / Utnyttja 18F-FDG PET/CT Imaging och kvantitativa…
JoVE Journal
Cancer Research

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JoVE Journal Cancer Research
Utnyttja 18F-FDG PET/CT Imaging och kvantitativa histologi för att mäta dynamiska förändringar i glukosmetabolism i musmodeller av lungcancer
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Utnyttja 18F-FDG PET/CT Imaging och kvantitativa histologi för att mäta dynamiska förändringar i glukosmetabolism i musmodeller av lungcancer

Article DOI: 10.3791/57167-v • 06:51 min • July 21st, 2018
July 21st, 2018 •
1, 2, 3, 3, 3, 1, 4, 5, 1
1Division of Pulmonary and Critical Care Medicine, University of California Los Angeles David Geffen School of Medicine, 2University of North Carolina at Chapel Hill, 3Department of Molecular and Medical Pharmacology, University of California Los Angeles, 4Andor Technology, 5Division of Orthopaedic Surgery, University of California Los Angeles David Geffen School of Medicine

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I detta protokoll beskriver vi hur du utnyttjar [18F]-2-fluoro-2-deoxy-D-glucose positron emissions tomografi och datortomografi (18F-FDG PET/CT) imaging för att mäta den tumör metabola Svaren till riktad terapi MLN0128 i en KRAS/Lkb1 mutant mouse modell av lungcancer och kopplat avbildning med hög upplösning ex vivo autoradiografi och kvantitativa histologi.

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Cancerforskning fråga 137 18F-FDG PET imaging lungcancer glykolys LKB1 KRAS mTOR
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