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A Rabbit Model of Durable Transgene Expression in Jugular Vein to Common Carotid Artery Interposition Grafts

Article DOI: 10.3791/57231-v • 13:58 min • September 10th, 2018
September 10th, 2018 •
*1, *1, 1
1Department of Medicine, University of Washington School of Medicine
* These authors contributed equally

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Summary
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This method describes the placement of interposition vein grafts in rabbits, the transduction of the grafts, and the achievement of durable transgene expression. This allows the investigation of physiological and pathological roles of transgenes and their protein products in grafted veins, and testing of gene therapies for vein graft disease.

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Rabbit Model Durable Transgene Expression Jugular Vein Common Carotid Artery Interposition Grafts Pathogenesis Vein Graft Failure Mediators Of Graft Failure Strategies For Preventing Graft Failure Stable Transgene Expression Vein Graft Endothelium Anesthetizing A Rabbit Surgical Setup Electrocautery Skin Incision Towel Clamps Blunt Dissection Fascia Sternal Hyoid Muscle Trachea Sternoephalic Muscle Common Carotid Artery Dissection Surrounding Tissues
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