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Journal / Genetics / Promotor Capture Hallo-c: Hochauflösende,…
JoVE Journal
Genetics

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JoVE Journal Genetics
Promotor Capture Hallo-c
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Promotor Capture Hallo-c: Hochauflösende, genomweite Profilierung der Promoter Interaktionen

Article DOI: 10.3791/57320-v • 10:16 min • June 28th, 2018
June 28th, 2018 •
*1, *1,2, 1,3, 1,4, 1,5
1Nuclear Dynamics Programme, The Babraham Institute, Babraham Research Campus, 2IJC Building, Campus ICO-Germans Trias i Pujol, Josep Carreras Leukemia Research Institute, 3Departamento de Genética Molecular, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, 4Bioinformatics Group, The Babraham Institute, Babraham Research Campus, 5Department of Biological Science, Florida State University
* These authors contributed equally

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DNA-regulatorische Elementen, wie z. B. Enhancer, Steuern Genexpression durch Kontaktaufnahme mit körperlich Ziel Gen Promotoren, oft durch weiträumige chromosomalen Interaktionen über genomische Entfernungen. Promotor erfassen Hi-C (PCHi-C) identifiziert signifikante Wechselwirkungen zwischen Promotoren und distalen Regionen ermöglicht die Zuordnung von möglichen regulatorischen Sequenzen, deren Zielgene.

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Ausgabe 136 3D Genom-Organisation Promotoren Enhancer Genetik langreichweitige Wechselwirkungen Hi-C Cis-regulatorischen Elementen genomweite Studie (GWAS) nicht-kodierenden Krankheit Varianten Chromatin Schleifen CHiCAGO HiCUP
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