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JoVE Journal Neuroscience
Kanüle Implantation in die Cisterna Magna von Nagetieren
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Kanüle Implantation in die Cisterna Magna von Nagetieren

Article DOI: 10.3791/57378-v • 10:13 min • May 23rd, 2018
May 23rd, 2018 •
1, 1, 1, 1, 1,2, 3, 3,4, 1,3
1Center for Translational Neuromedicine, Division of Glial Therapeutics, University of Copenhagen, 2Department of Anesthesiology, Yale School of Medicine, 3Center for Translational Neuromedicine, Division of Glial Therapeutics, University of Rochester Medical Center, 4Department of Experimental Medical Science, Wallenberg Center for Molecular Medicine, Lund University

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Hier beschreiben wir ein Protokoll zur Durchführung der Cisterna Magna Kanülierung (CMc), minimalinvasiv, Tracer, Substrate und Signalmoleküle in den Liquor cerebrospinalis (CSF) zu liefern. In Kombination mit verschiedenen Bildgebungsverfahren ermöglicht CMc Glymphatic System sowie CSF Dynamik Bewertung und Gehirn-weite Lieferung verschiedener Verbindungen.

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Neurowissenschaften Ausgabe 135 zerebrospinale Flüssigkeit (CSF) interstitielle Flüssigkeit (ISF) Subarachnoidalraum Glymphatic System Cisterna Magna (CM) Cisterna Magna Kanülierung (CMc) Nagetiere Magnetresonanz-Tomographie (MRI) Epifluoreszenz 2-Photonen-Mikroskopie
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