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Journal / Neuroscience / Tilpasning af mikroelektrode Array teknologi for…
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Neuroscience

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JoVE Journal Neuroscience
Tilpasning af mikroelektrode Array teknologi for studiet af anæstesi-induceret neurotoksicitet i hjernen, intakt Grisling
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Tilpasning af mikroelektrode Array teknologi for studiet af anæstesi-induceret neurotoksicitet i hjernen, intakt Grisling

Article DOI: 10.3791/57391-v • 08:23 min • May 12th, 2018
May 12th, 2018 •
*1, *1, *1, *1,2, *1,2, *1,3, 1, 4, 4, 4, 1,3
1Department of Anesthesiology, Ohio State University College of Medicine, 2Medical Student Research Program, Ohio State University College of Medicine, 3Department of Anesthesiology and Pain Medicine, Nationwide Children's Hospital, 4Department of Neuroscience, University of Kentucky Medical Center
* These authors contributed equally

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Denne undersøgelse udforsker den roman brug af enzym-baserede mikroelektrode array (MEA) teknologi til at overvåge i vivo neurotransmitter aktivitet i smågrise. Hypotesen var, at glutamat dysregulering bidrager til mekanismen af bedøvelsesmiddel neurotoksicitet. Vi præsenterer her, en protokol for at tilpasse MEA teknologi for at studere mekanismen af anæstesi-induceret neurotoksicitet.

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Neurovidenskab spørgsmålet 135 glutamat hippocampus neurotransmittere neuroinflammation forstyrrelser i nervesystemets udvikling Sevofluran pædiatrisk anæstesi
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