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Journal / Genetics / クロマチンのループ構造の再編を CRISPR…
JoVE Journal
Genetics

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JoVE Journal Genetics
クロマチンのループ構造の再編を CRISPR 媒介
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クロマチンのループ構造の再編を CRISPR 媒介

Article DOI: 10.3791/57457-v • 09:20 min • September 14th, 2018
September 14th, 2018 •
*1,2, *1, 1, 3, 4, 5, 1, 1, 1, 5, 3, 1,2,6
1Department of Dermatology, Program in Epithelial Biology, Stanford University School of Medicine, 2Program in Cancer Biology, Stanford University School of Medicine, 3Canary Center for Cancer Early Detection, Department of Radiology, Stanford University School of Medicine, 4Department of Biology, Bridgewater State University, 5System Biosciences, 6Veterans Affairs Healthcare System
* These authors contributed equally

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遺伝子発現制御に重要な役割を果たしているクロマチンのループただし、クロマチンのループの選択的かつ可逆的な変更を可能にする技術の進歩はいません。ここでクロマチンのループの再編成のための強力なシステムを記述対象遺伝子座に CRISPR dCas9 (CLOuD9) を使用して、選択的かつ可逆的に遺伝子発現を調節することが実証します。

Tags

遺伝学、問題 139、クロマチンのループ、クロマチンの折りたたみ、遺伝子発現、CRISPR、dCas9、遺伝子発現制御、リバーシブル二量体化、動的の染色体の語順換え。
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