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Journal / Developmental Biology / En familiær hyperkolesterolæmi menneskelige lever …
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Developmental Biology

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JoVE Journal Developmental Biology
En familiær hyperkolesterolæmi menneskelige lever kimære musen Model ved hjælp af induceret pluripotente stamceller-afledt hepatocytter
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En familiær hyperkolesterolæmi menneskelige lever kimære musen Model ved hjælp af induceret pluripotente stamceller-afledt hepatocytter

Article DOI: 10.3791/57556-v • 10:56 min • September 15th, 2018
September 15th, 2018 •
*1,2,6, *2, *3, 1,2, 2, 2, 4,5, 4,5, 2, 4,5, 4,5, 4,5, 4,5, 3, 4,5,7, 1,2,6,7
1Department of Medicine, University of Hong Kong-Shenzhen Hospital, 2The Cardiology Division, Department of Medicine, Li Ka Shing Faculty of Medicine, University of Hong Kong, 3School of Biomedical Sciences, Institute of Vascular Medicine, Li Ka Shing Institute of Health Sciences, Chinese University of Hong Kong, 4Key Laboratory of Regenerative Biology of the Chinese Academy of Sciences, Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health and Guangzhou Medical University, 5Laboratory of RNA, Chromatin, and Human Disease, CAS Key Laboratory of Regenerative Biology and Guangdong Provincial Key Laboratory of Stem Cells and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, 6Research Centre of Heart, Brain, Hormone, and Healthy Ageing, Li Ka Shing Faculty of Medicine, University of Hong Kong, 7Hong Kong-Guangdong Stem Cell and Regenerative Medicine Research Centre, University of Hong Kong and Guangzhou Institutes of Biomedicine and Health
* These authors contributed equally

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Vi præsenterer her, en protokol for at generere en menneskelig lever kimære musemodel af familiær hyperkolesterolæmi ved hjælp af menneskelige inducerede pluripotente stamceller-afledt hepatocytter. Dette er en værdifuld model til at teste nye behandlinger for hyperkolesterolæmi.

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Udviklingsmæssige biologi sag 139 Familial hyperkolesterolæmi hepatocytter menneskelige lever kimære Mus induceret pluripotente stamceller LDL-receptor statiner PCSK9 antistoffer
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