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Adeno-assosiert Virus-mediert levering av CRISPR for Cardiac genet redigering i mus
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Adeno-assosiert Virus-mediert levering av CRISPR for Cardiac genet redigering i mus

Article DOI: 10.3791/57560-v • 09:00 min • August 2nd, 2018
August 2nd, 2018 •
1, 1, 1, 1
1Department of Surgery, Davis Heart and Lung Research Institute, Biomedical Sciences Graduate Program, Biophysics Graduate Program, Ohio State University Wexner Medical Center

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Her vi gir en detaljert protokoll til å utføre i vivo cardiac genet redigering i mus ved hjelp av rekombinant Adeno-Associated Virus (rAAV)-mediert levering av CRISPR. Denne protokollen tilbyr en lovende terapeutiske strategi for å behandle dystrophic kardiomyopati i Duchenne muskeldystrofi og kan brukes til å generere hjerte-spesifikke knockout i postnatal mus.

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Medisin problemet 138 AAV CRISPR Duchenne muskeldystrofi dystrophin gen redigering mdx rekombinant adeno-assosiert virus
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