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Journal / Medicine / Virüs-aracılı teslim CRISPR kardiyak Gene…
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Virüs-aracılı teslim CRISPR kardiyak Gene farelerde düzenleme için Adeno ilişkili
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Virüs-aracılı teslim CRISPR kardiyak Gene farelerde düzenleme için Adeno ilişkili

Article DOI: 10.3791/57560-v • 09:00 min • August 2nd, 2018
August 2nd, 2018 •
1, 1, 1, 1
1Department of Surgery, Davis Heart and Lung Research Institute, Biomedical Sciences Graduate Program, Biophysics Graduate Program, Ohio State University Wexner Medical Center

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Burada vivo içinde kalp gen rekombinant Adeno-Associated virüs (rAAV) kullanarak farelerde düzenleme taşımak için detaylı bir protokol sağlamak-CRISPR teslimini aracılı. Bu iletişim kuralı distrofik kardiyomiyopati Duchenne kas distrofisi tedavisinde umut verici bir tedavi stratejisi teklifler ve kardiyak özgü nakavt postnatal farelerde oluşturmak için kullanılabilir.

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Tıp sayı 138 AAV CRISPR Duchenne kas distrofisi dystrophin gen düzenleme mdx rekombinant adeno ilişkili virüs
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