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JoVE Journal Cancer Research
应用 Fraumeni 综合征诱导多潜能干细胞建模骨肉瘤
Morphology-Based Distinction Between Healthy and Pathological Cells Utilizing Fourier Transforms and Self-Organizing Maps
Journal (Cancer Research)
Morphology-Based Distinction Between Healthy and Pathological Cells Utilizing Fourier Transforms and Self-Organizing Maps
Target Cell Pre-enrichment and Whole Genome Amplification for Single Cell Downstream Characterization
Journal (Cancer Research)
Target Cell Pre-enrichment and Whole Genome Amplification for Single Cell Downstream Characterization
 
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应用 Fraumeni 综合征诱导多潜能干细胞建模骨肉瘤

Article DOI: 10.3791/57664-v • 08:52 min • June 13th, 2018
June 13th, 2018 •
1,2, 1, 1,3, 1, 4, 1, 1,2,5,6
1Department of Integrative Biology and Pharmacology, McGovern Medical School, The University of Texas Health Science Center at Houston, 2Graduate School of Biomedical Sciences, The University of Texas MD Anderson Cancer Center UTHealth, 3Department of Musculoskeletal Oncology, The First Affiliated Hospital of Sun Yat-sen University, 4Women's Health Institute, Cleveland Clinic Foundation, 5Center for Stem Cell and Regenerative Medicine, The Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases, The University of Texas Health Science Center at Houston, 6Center for Precision Health, School of Biomedical Informatics and School of Public Health, The University of Texas Health Science Center at Houston

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在这里, 我们提出了一个由李-Fraumeni 综合征 (LFS) 患者衍生成纤维细胞生成诱导多能干细胞 (iPSCs) 的协议, 通过间充质干细胞 (MSCs) 分化成成骨细胞, 并在体内建模利用 LFS 患者源性成骨细胞进行肿瘤发生。

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癌症研究 问题 136 iPSCs Fraumeni 综合征 重编程 分化 间充质干细胞 成骨细胞 骨肉瘤 异种异体
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