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Journal / Genetics / Bronchoalveolar Lavage Exosomes…
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Bronchoalveolar Lavage Exosomes lipopolysakkarid-indusert septisk lungen skade
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Bronchoalveolar Lavage Exosomes lipopolysakkarid-indusert septisk lungen skade

Article DOI: 10.3791/57737-v • 08:27 min • May 21st, 2018
May 21st, 2018 •
1,2, 1, 1,2
1Department of Veterans Affairs, Atlanta VAMC, 2Division of Pulmonary and Critical Care Medicine, Department of Medicine, Emory University

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Mus utsatt for intraperitoneal LPS skiller exosomes i Broncho-alveolar lavage (BAL) væske som er pakket med miRNAs. Bruker en co kultur, viser vi at exosomes utgitt i BAL væske forstyrre uttrykk for tett krysset proteiner i bronkial epitelceller og øke uttrykk for pro-inflammatoriske cytokiner som fremhever lungen skade.

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Genetikk problemet 135 Exosomes microRNAs miR-155 miR-146a LP-plater lunge sepsis
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