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JoVE Journal Genetics
Bronkoalveolär Lavage Exosomes i lipopolysackarid-inducerad septisk lungskada
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Bronkoalveolär Lavage Exosomes i lipopolysackarid-inducerad septisk lungskada

Article DOI: 10.3791/57737-v • 08:27 min • May 21st, 2018
May 21st, 2018 •
1,2, 1, 1,2
1Department of Veterans Affairs, Atlanta VAMC, 2Division of Pulmonary and Critical Care Medicine, Department of Medicine, Emory University

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Möss som utsätts för intraperitoneal LPS utsöndrar exosomes i Bronko-alveolar lavage (BAL) vätska som paketeras med microRNA. Samtidig kultur system med visar vi att exosomes släppt i BAL vätska störa uttrycket av åtsittande föreningspunkt proteiner i bronkial epitelceller och öka uttrycket av pro-inflammatoriska cytokiner som framhäver lungskada.

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Genetik fråga 135 Exosomes mikroRNA miR-155 miR-146a LPS lung- sepsis
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