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Journal / Cancer Research / Immunoglobuline Gene sequentieanalyse In…
JoVE Journal
Cancer Research

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JoVE Journal Cancer Research
Immunoglobuline Gene sequentieanalyse In chronische lymfatische leukemie
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Journal (Cancer Research)
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Immunoglobuline Gene sequentieanalyse In chronische lymfatische leukemie: Van patiënt materiaal reeks interpretatie

Article DOI: 10.3791/57787-v • 09:02 min • November 26th, 2018
November 26th, 2018 •
*1, *2,3, 1, 4, 5, 6, 7, 2,3, 1,2, 8
1Institute of Applied Biosciences, Centre for Research and Technology Hellas, 2Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, 3Department of Molecular Medicine and Surgery, Karolinska Institutet, 4Division of Immunology, Transplantation and Infectious, IRCCS San Raffaele Scientific Institute, 5Department of Immunology, Laboratory for Medical Immunology, Erasmus University Medical Center, 6Hematology Department, Nikea General Hospital, 7Assistance publique - Hôpitaux de Paris (AP-HP), Hopital Pitié-Salpêtrière, Department of Hematology, and UPMC University Paris 06, UMRS 1138, 8Division of Experimental Oncology, IRCCS Istituto Scientifico San Raffaele and Università Vita-Salute San Raffaele
* These authors contributed equally

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Hierin presenteren wij een protocol dat details de technische aspecten en essentiële eisen om robuuste IG gene sequentieanalyse bij patiënten met chronische lymfatische leukemie (CLL), gebaseerd op de opgedane ervaring van het initiatief van het Europeseonderzoek op CLL (ERIC).

Tags

Kankeronderzoek kwestie 141 chronische lymfatische leukemie (CLL) somatische hypermutation (SHM) immunoglobuline immunoglobulin zwaar variabele (IGHV) complementariteit bepalen regio 3 (CDR3) International Immunogenetica informatiesysteem (IMGT)
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