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Bioengineering

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JoVE Journal Bioengineering
Bioprintable calciumalginat/gelatine Hydrogel 3D In Vitro modelsystemer fremkalde celle klumpformet dannelse
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Bioprintable calciumalginat/gelatine Hydrogel 3D In Vitro modelsystemer fremkalde celle klumpformet dannelse

Article DOI: 10.3791/57826-v • 16:20 min • July 2nd, 2018
July 2nd, 2018 •
*1, *2,3, 2, 4, 4, 3, 2,5
1Department of Mechanical Engineering, McGill University Montreal, 2Department of Bioengineering, McGill University Montreal, 3Department of Molecular Biology, Instituto Potosino de Investigación Científica y Tecnológica, A.C. (IPICyT), 4Department of Mining and Materials Engineering, McGill University Montreal, 5Department of Biomedical Engineering, McGill University Montreal
* These authors contributed equally

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Vi udviklede en heterogen bryst kræft model bestående af udødeliggjort tumor og fibroblast celler indlejret i en bioprintable calciumalginat/gelatine bioink. Modellen sammenfatter i vivo tumor mikromiljø og letter dannelsen af flercellede tumor spheroids, giver indsigt i de mekanismer, der driver tumordannelse.

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Bioteknologi sag 137 3D bioprinting hydrogel kræftceller tumor spheroids natriumalginat gelatine
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