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Journal / Developmental Biology / 従来のひと多能性幹細胞の向上多能分化と素朴なような状態の復帰化学…
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Developmental Biology

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JoVE Journal Developmental Biology
従来のひと多能性幹細胞の向上多能分化と素朴なような状態の復帰化学
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従来のひと多能性幹細胞の向上多能分化と素朴なような状態の復帰化学

Article DOI: 10.3791/57921-v • 09:07 min • June 10th, 2018
June 10th, 2018 •
*1, *1, 1, 1
1Department of Oncology, Division of Pediatric Oncology and Institute for Cell Engineering, Johns Hopkins School of Medicine
* These authors contributed equally

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効率的な一括、および急速な化学復帰従来系列プライミングひと多能性幹細胞 (hPSC) の epigenomically 安定した素朴な着床前胚盤葉上層のような多能性状態にするためのプロトコルを提案します。このメソッド結果減少系統プライミング遺伝子発現と分化多能でマーク付きの改善で従来の hPSC ラインの幅広いレパートリー。

Tags

発生生物学、問題 136、素朴な多能性、ひと多能性幹細胞、分化、タンキラーゼ抑制、小分子、胚盤葉上層
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