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Diferença de potencial nasal para quantificar o transporte do íon Trans-epitelial em ratos
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Diferença de potencial nasal para quantificar o transporte do íon Trans-epitelial em ratos

Article DOI: 10.3791/57934-v • 08:55 min • July 4th, 2018
July 4th, 2018 •
1, 1
1Louvain Center for Toxicology and Applied Pharmacology (LTAP), Institut de Recherche Expérimentale et Clinique (IREC), Université Catholique de Louvain

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Aqui, apresentamos um protocolo para medir a diferença de potencial nasal em ratos. O teste quantifica a função de transportadores transmembrana de íons como o regulador de condutância transmembranar de fibrose cística e o canal de sódio epitelial. É valioso para avaliar a eficácia de novas terapias para a fibrose cística.

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Biologia questão 137 fibrose cística CFTR ENaC diferença de potencial nasal transporte de íons modelos do rato da doença biomarcador de efeito terapêutico diagnóstico
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