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JoVE Journal Neuroscience
Generation og On-Demand indledning af akut Ictal aktivitet i gnaver og menneskeligt væv
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Generation og On-Demand indledning af akut Ictal aktivitet i gnaver og menneskeligt væv

Article DOI: 10.3791/57952-v • 06:45 min • January 19th, 2019
January 19th, 2019 •
1,2, 1,3, 1,2,3,5,6, 1,2,3,4
1Division of Fundamental Neurobiology, Krembil Research Institute, 2Institute of Medical Science, Faculty of Medicine, University of Toronto, 3Institute of Biomaterials and Biomedical Engineering, University of Toronto, 4Division of Neurosurgery, Department of Surgery, University of Toronto, 5Division of Neurology, Department of Medicine, University of Toronto, 6Department of Physiology, University of Toronto

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Akutte anfald modeller er vigtige for at studere de underliggende epileptiform begivenheder mekanismer. Desuden giver evnen til at generere epileptiform begivenheder på efterspørgsel en meget effektiv metode til at studere den nøjagtige rækkefølge af begivenheder ligger til grund for deres indledning. Her beskriver vi de akutte 4-aminopyridine kortikale beslaglæggelse modeller etableret i mus og humant væv.

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Neurovidenskab spørgsmålet 143 Epileptiform beslaglæggelse ictal interictal 4-AP optogenetic ChR2 GABA on demand cortex hippocampus
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