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Iniciação de geração e demanda de atividade estável aguda em roedores e tecido humano
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Iniciação de geração e demanda de atividade estável aguda em roedores e tecido humano

Article DOI: 10.3791/57952-v • 06:45 min • January 19th, 2019
January 19th, 2019 •
1,2, 1,3, 1,2,3,5,6, 1,2,3,4
1Division of Fundamental Neurobiology, Krembil Research Institute, 2Institute of Medical Science, Faculty of Medicine, University of Toronto, 3Institute of Biomaterials and Biomedical Engineering, University of Toronto, 4Division of Neurosurgery, Department of Surgery, University of Toronto, 5Division of Neurology, Department of Medicine, University of Toronto, 6Department of Physiology, University of Toronto

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Modelos de convulsão aguda são importantes para estudar os mecanismos subjacentes epileptiforme eventos. Além disso, a capacidade de gerar eventos epileptiforme sob demanda fornece um método altamente eficiente para estudar a sequência exata de eventos subjacentes a sua iniciação. Aqui, descrevemos os modelos de apreensão cortical aguda 4-aminopiridina estabelecidos em mouse e tecido humano.

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Neurociência edição 143 epileptiforme apreensão estável interictais 4-AP optogenetic ChR2 GABA sob demanda córtex hipocampo
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