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JoVE Journal Biology
SA-β-galactosidase-baseret Screenings analyse til identifikation af Senotherapeutiske lægemidler
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SA-β-galactosidase-baseret Screenings analyse til identifikation af Senotherapeutiske lægemidler

Article DOI: 10.3791/58133-v • 07:39 min • June 28th, 2019
June 28th, 2019 •
*1, *1,2,3, 1, 1, 1,2,3, 1,2,3
1Department of Molecular Medicine and the Center on Aging, The Scripps Research Institute, 2Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, 3Institute on the Biology of Aging and Metabolism, University of Minnesota
* These authors contributed equally

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Cellulær senescens er den vigtigste faktor i udviklingen af kroniske aldersrelaterede patologier. Identifikation af Therapeutics at målrette senescent celler viser løfte om at forlænge sund aldring. Her præsenterer vi en ny analyse til at screene for identifikation af senotherapeutika baseret på måling af senescens associeret β-galactosidase aktivitet i enkeltceller.

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Biologi aldring celle senescens celledød Senescence associeret β-galactosidase høj gennemløbs screening Senolytika Senomorffer Senotherapeutika
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