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Bioengineering

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JoVE Journal Bioengineering
Valutazione globale dell'efficacia e della sicurezza di Placenta-Targeted Drug Delivery utilizzando tre metodi complementari
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Valutazione globale dell'efficacia e della sicurezza di Placenta-Targeted Drug Delivery utilizzando tre metodi complementari

Article DOI: 10.3791/58219-v • 09:04 min • September 10th, 2018
September 10th, 2018 •
1, 1,2, 1,3, 1, 4, 1
1Laboratory for Reproductive Health, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, 2College of Veterinary Medicine, Hunan Agricultural University, 3Key Laboratory of Chemical Engineering Process and Technology for High-efficiency Conversion, College of Chemistry and Material Sciences, Heilongjiang University, 4Department of Obstetrics and Gynecology, Wayne State University School of Medicine

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Descriviamo un sistema che utilizza tre metodi per valutare la sicurezza e l'efficacia della somministrazione di farmaci mirati placenta: in vivo imaging per monitorare l'accumulo delle nanoparticelle, ultrasuono ad alta frequenza per monitorare lo sviluppo placenta e fetale e HPLC per quantificare la consegna della droga al tessuto.

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Bioingegneria numero 139 in vivo imaging ad alta frequenza ultrasuoni cromatografia liquida ad alte prestazioni placentare Condroitin solfato A associazione peptide nanoparticelle placenta di targeting complicanze della gravidanza
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