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JoVE Journal Bioengineering
Undertrykke gen transskription ved at omdirigere cellulære maskiner med kemiske epigenetiske modifikatorer
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Undertrykke gen transskription ved at omdirigere cellulære maskiner med kemiske epigenetiske modifikatorer

Article DOI: 10.3791/58222-v • 10:28 min • September 20th, 2018
September 20th, 2018 •
1, 2, 3, 3, 4
1Chemical Biology and Medicinal Chemistry, Center for Integrative Chemical Biology and Drug Discovery, Curriculum in Genetics and Molecular Biology, University of North Carolina, 2College of Arts and Sciences, Chemical Biology and Medicinal Chemistry, Center for Integrative Chemical Biology and Drug Discovery, University of North Carolina, 3Chemical Biology and Drug Discovery, Pharmacological Sciences and Oncological Sciences, Icahn School of Medicine at Mount Sinai, 4Chemical Biology and Medicinal Chemistry, Center for Integrative Chemical Biology and Drug Discovery, Curriculum in Genetics and Molecular Biology, Lineberger Comprehensive Cancer Center, University of North Carolina

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Regulering af kromatin miljø er en afgørende proces kræves for korrekt genekspression. Her, vi beskriver en metode til at kontrollere genekspression gennem ansættelse af ændring af kromatin maskiner i en gen-specifikke og reversibel måde.

Tags

Bioteknologi sag 139 kemisk biologi bifunctional molekyler kemiske induceret nærhed kromatin forordning gen undertrykkelse Histon deacetylase Epigenetik kemiske epigenetiske modifikatorer CEMs
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