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Journal / Immunology and Infection / Humaniserad nicka/SCID/IL2rγnull (hu-NSG) mus…
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Immunology and Infection

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JoVE Journal Immunology and Infection
Humaniserad nicka/SCID/IL2rγnull (hu-NSG) mus modell för hivreplikation och latens studier
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Humaniserad nicka/SCID/IL2rγnull (hu-NSG) mus modell för hivreplikation och latens studier

Article DOI: 10.3791/58255-v • 07:10 min • January 7th, 2019
January 7th, 2019 •
1, 1, 1,2, 1, 1
1Department of Molecular and Cellular Biology, Beckman Research Institute of City of Hope, 2Irell and Manela Graduate School of Biological Sciences, Beckman Research Institute of City of Hope

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Detta protokoll ger en metod för att fastställa humaniserade möss (hu-NSG) via intrahepatisk injektion av hematopoetiska stamceller i strålning-villkorade neonatal NSG möss. Hu-NSG musen är mottagliga för HIV-infektion och kombinatoriska antiretroviral kombinationsbehandling (cART) och fungerar som en lämplig patofysiologiska modell för HIV replikation och latens utredningar.

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Immunologi och infektion fråga 143 Neonatal NSG mus humaniserad möss Förenta HIV vagn latens
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