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En kromatin Immunoprecipitation analysen identifiera roman NFAT2 målgener i kronisk lymfatisk leukemi
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En kromatin Immunoprecipitation analysen identifiera roman NFAT2 målgener i kronisk lymfatisk leukemi

Article DOI: 10.3791/58270-v • 09:52 min • December 4th, 2018
December 4th, 2018 •
1, 1, 1, 1, 2, 1, 1, 1, 1, 1
1Dept. of Hematology, Oncology and Immunology, University of Tübingen, 2Dept. of Endocrinology, Diabetology, Clinical Pathology and Metabolism, University of Tübingen

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Kronisk lymfatisk leukemi (KLL) är den vanligaste leukemi i västvärlden. NFAT transkriptionsfaktorer är viktiga regulatorer av utveckling och aktivering i många celltyper. Här presenterar vi ett protokoll för användning av kromatin immunoprecipitation (ChIP) i mänskliga KLL celler att identifiera nya målgener av NFAT2.

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Cancerforskning fråga 142 KLL NFAT transkriptionsfaktor målgenen promotorn kromatin immunoprecipitation
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