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Journal / Cancer Research / Surface-förbättrade resonans Raman spridning…
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Cancer Research

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JoVE Journal Cancer Research
Surface-förbättrade resonans Raman spridning Nanoprobe Ratiometry för att upptäcka mikroskopisk äggstockscancer via folat Receptor inriktning
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Surface-förbättrade resonans Raman spridning Nanoprobe Ratiometry för att upptäcka mikroskopisk äggstockscancer via folat Receptor inriktning

Article DOI: 10.3791/58389-v • 07:54 min • March 25th, 2019
March 25th, 2019 •
1, 1, 1, 1,2, 1, 1,3,4,5,6,7
1Department of Radiology, Memorial Sloan Kettering Cancer Center, 2Department of Chemistry, The Graduate Center of the City University of New York, 3Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, 4Center for Molecular Imaging and Nanotechnology (CMINT), Memorial Sloan Kettering Cancer Center, 5Gerstner Sloan Kettering Graduate School of Biomedical Sciences, 6Department of Radiology, Weill Cornell Medical College of Cornell University, 7Dana-Farber Cancer Institute and Harvard Medical Center

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Äggstockscancer bildar metastaser i hela i bukhålan. Här presenterar vi ett protokoll att göra och använda folat-receptor riktade ytan-förbättrade resonans Raman scattering nanoprober som avslöjar dessa lesioner med hög specificitet via proportionerlig imaging. Nanoprober administreras intraperitonealt till levande möss, och de härledda bilderna korrelerar väl med histologi.

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Cancerforskning fråga 145 Raman SERS nanopartiklar molekylär imaging äggstockscancer folat receptor ratiometry
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