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JoVE Journal Cancer Research
Monitoramento de hipopótamo, sinalizando o Pathway atividade usando um Tumor grande baseado em Luciferase supressor (LATS) Biosensor
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Monitoramento de hipopótamo, sinalizando o Pathway atividade usando um Tumor grande baseado em Luciferase supressor (LATS) Biosensor

Article DOI: 10.3791/58416-v • 07:16 min • September 13th, 2018
September 13th, 2018 •
*1, *1, 1, 1, 1
1Department of Pathology and Molecular Medicine, Queen's University
* These authors contributed equally

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Aqui nós apresentamos um biossensor baseado em luciferase para quantificar a atividade da quinase do supressor do tumor grande (LATS)-uma quinase central no Hippo via de sinalização. Este biosensor tem diversas aplicações na pesquisa básica e translacional, visa investigar hipopótamo via reguladores in vitro e em vivo.

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Pesquisa sobre o câncer edição 139 LATS biosensor LATS caminho de hipopótamo dividir o ensaio de luciferase cultura celular triagem de drogas quinase
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