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Journal / Cancer Research / Überwachung von Hippo Signalisierung…
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Cancer Research

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JoVE Journal Cancer Research
Überwachung von Hippo Signalisierung Pathway-Aktivität unter Verwendung eines Biosensors Luciferase-basierte großen Tumorsuppressor (LATS)
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Überwachung von Hippo Signalisierung Pathway-Aktivität unter Verwendung eines Biosensors Luciferase-basierte großen Tumorsuppressor (LATS)

Article DOI: 10.3791/58416-v • 07:16 min • September 13th, 2018
September 13th, 2018 •
*1, *1, 1, 1, 1
1Department of Pathology and Molecular Medicine, Queen's University
* These authors contributed equally

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Hier präsentieren wir Ihnen eine Luciferase-basierten Biosensor zur Quantifizierung der Kinase-Aktivität von großen Tumorsuppressor (LATS)-einer zentralen Kinase in den Signalweg Hippo. Diese Biosensor hat vielfältige Anwendungen in Grundlagen- und Translationale Forschung zur Hippo Weg Regulierungsbehörden in Vitro und in Vivozu untersuchen.

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Cancer Research Ausgabe 139 LATS LATS Biosensor Hippo Weg split-Luciferase Assay Zellkultur Drogen-Screening Kinase
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