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Myeloid medfødte signalnettverk Pathway regulering av MALT1 Paracaspase aktivitet
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Myeloid medfødte signalnettverk Pathway regulering av MALT1 Paracaspase aktivitet

Article DOI: 10.3791/58439-v • 07:09 min • January 7th, 2019
January 7th, 2019 •
*1, *1, 1, 1, 1, 1, 1
1Autoimmunity, Transplantation and Inflammation, Novartis Institutes for BioMedical Research
* These authors contributed equally

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MALT1 regulerer medfødt immunitet men hvordan dette skjer fortsatt dårlig definerte. Vi brukte den selektive MALT1 paracaspase inhibitor MLT-827 for å rakne bidraget fra MALT1 til medfødte signalering nedstrøms Toll-like eller C-type Lektiner-like reseptorer, viser at MALT1 regulerer produksjonen av myelogen cytokiner, og nedstrøms av C-type Lektiner-like reseptorer, selektivt.

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Biologi problemet 143 MALT1 paracaspase Dectin MINCLE Toll-like reseptor protease hemming myeloide celler CBM komplekse
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