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Journal / Chemistry / Solid-phase synthese van [4.4] Spirocyclic Oximes
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Solid-phase synthese van [4.4] Spirocyclic Oximes
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Solid-phase synthese van [4.4] Spirocyclic Oximes

Article DOI: 10.3791/58508-v • 05:15 min • February 6th, 2019
February 6th, 2019 •
1, 1, 1
1Department of Biology and Chemistry, Azusa Pacific University

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Hier presenteren we een protocol om aan te tonen van een efficiënte methode voor de synthese van spirocyclic heterocycles. De vijf-stap proces maakt gebruik van solid-phase synthese en regenereren van Michael linker strategieën. Over het algemeen moeilijk te synthetiseren, presenteren we een aanpasbare methode voor de synthese van spirocyclic moleculen anders ontoegankelijk is voor andere moderne benaderingen.

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Chemie kwestie 144 Solid-phase synthese regenereren Michael linker intramoleculaire 1,3-Dipolaire cycloadditie spirocyclic heterocycles tricyclische tussenliggende hoge diastereoselectivity
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