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Methionin Funktionaliserede biokompatible blok copolymere til målrettet plasmid DNA levering

Article DOI: 10.3791/58527-v • 08:09 min • August 6th, 2019
August 6th, 2019 •
*1, *2, 2, 3, 2, 3, 1, 2
1Research Center of Clinical Oncology, Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research & Nanjing Medical University Affiliated Cancer Hospital, 2Department of General Surgery, The First Affiliated Hospital with Nanjing Medical University, 3School of Clinical Medicine, Xuzhou Medical University
* These authors contributed equally

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Dette arbejde præsenterer forberedelsen af methionin funktionaliserede biokompatible blok copolymere (mBG) via den reversible tilsætning-fragmentering kæde overførsel (RAFT) metode. Plasmid-DNA-kompleksdannsevnen for den opnåede MBG og deres transfektering effektivitet blev også undersøgt. FLÅDEN metode er meget gavnlig for polymeriserende monomerer indeholder særlige funktionelle grupper.

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Kemi reversibel tilsætning-fragmentering kæde overførsel TØMMERFLÅDE Drug delivery system DDS methionin guanidin N-(3-aminopropyl) methacrylamid hydrochlorid APMA n,n-bis(2-hydroxyethyl) methacrylamid BNHEMA
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