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JoVE Journal Chemistry
Methionine Gefunctionaliseerde biocompatibele blok copolymeren voor gerichte plasmide DNA-levering
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Methionine Gefunctionaliseerde biocompatibele blok copolymeren voor gerichte plasmide DNA-levering

Article DOI: 10.3791/58527-v • 08:09 min • August 6th, 2019
August 6th, 2019 •
*1, *2, 2, 3, 2, 3, 1, 2
1Research Center of Clinical Oncology, Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research & Nanjing Medical University Affiliated Cancer Hospital, 2Department of General Surgery, The First Affiliated Hospital with Nanjing Medical University, 3School of Clinical Medicine, Xuzhou Medical University
* These authors contributed equally

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Dit werk presenteert de voorbereiding van methionine Gefunctionaliseerde biocompatibele blok copolymeren (mBG) via de omkeerbare addition-fragmentatie Chain Transfer (RAFT) methode. De plasmide DNA-complexering van het verkregen mBG en hun transfectie efficiëntie werden ook onderzocht. De RAFT methode is zeer gunstig voor polymerisatie monomeren met speciale functionele groepen.

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Chemie uitgave 150 omkeerbare toevoeging-fragmentatie keten overdracht RAFT drug delivery systeem DDS methionine guanidine N-(3-aminopropyl) methacrylamidehydrochloride APMA n,n-bis(2-hydroxyethyl) methacrylamide BNHEMA
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