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JoVE Journal
Immunology and Infection

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JoVE Journal Immunology and Infection

HIV関連肝病因に対する二重ヒト化TK-NOGマウスモデルの確立

Studying Organelle Dynamics in B Cells During Immune Synapse Formation

Journal (Immunology and Infection)

Studying Organelle Dynamics in B Cells During Immune Synapse Formation

Rearing and Injection of Manduca sexta Larvae to Assess Bacterial Virulence

Journal (Immunology and Infection)

Rearing and Injection of Manduca sexta Larvae to Assess Bacterial Virulence

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HIV関連肝病因に対する二重ヒト化TK-NOGマウスモデルの確立

Article DOI: 10.3791/58645-v • 10:12 min • September 11th, 2019

September 11th, 2019 •

Raghubendra Singh Dagur¹, Weimin Wang¹, Edward Makarov¹, Yimin Sun², Larisa Y. Poluektova¹

¹Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, ²Department of Pathology and Microbiology, University of Nebraska Medical Center

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このプロトコルは、ヒト免疫系および肝細胞の両方を有するヒト化マウスを確立するための信頼性の高い方法を提供する。ヒト肝細胞およびCD34+造血幹細胞の脾臓内注射を介して達成される二重再構成免疫不全マウスは、ヒト免疫不全ウイルス-1感染の影響を受けやすく、肝臓損傷を再キャパチレートするHIVに感染した患者

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免疫学および感染症,問題151,二重ヒト化マウス,アルブミン,肝細胞,ヒト免疫システム,ヒト免疫不全ウイルス-1(HIV-1),造血幹細胞,造血前駆細胞

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