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Immunology and Infection

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JoVE Journal Immunology and Infection
Etablering av dual Humanisert TK-NOG Mouse modell for HIV-assosiert Liver patogenesen
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Etablering av dual Humanisert TK-NOG Mouse modell for HIV-assosiert Liver patogenesen

Article DOI: 10.3791/58645-v • 10:12 min • September 11th, 2019
September 11th, 2019 •
1, 1, 1, 2, 1
1Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, 2Department of Pathology and Microbiology, University of Nebraska Medical Center

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Denne protokollen gir en pålitelig metode for å etablere humanisert mus med både humant immunsystem og leverceller. Dual rekonstituert immunodeficient mus oppnådd via intrasplenic injeksjon av menneskelig HEPATOCYTTER og CD34+ blodkreft stamceller er mottakelige for humant immunsviktvirus-1 infeksjon og recapitulate leverskader som observert i HIV-infiserte pasienter.

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Immunologi og infeksjon dual humanisert mus albumin hepatocytter humanisert lever humant immunsystem humant immunsviktvirus-1 (HIV-1) blodkreft stamceller blodkreft stamceller
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