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JoVE Journal Cancer Research
Paramyxoviruses for svulst målrettede Immunomodulation
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Paramyxoviruses for svulst målrettede Immunomodulation: Design og evaluering Ex Vivo

Article DOI: 10.3791/58651-v • 12:42 min • January 7th, 2019
January 7th, 2019 •
1,2, 1,3
1Department of Translational Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), 2Faculty of Biosciences, Heidelberg University, 3Department of Medical Oncology, NCT and Heidelberg University Hospital

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Denne protokollen beskriver en detaljert arbeidsflyt for generering og ex vivo karakterisering av kan virus for uttrykk for immunomodulators, ved hjelp av meslinger virus koding bispecific T celle engagers som et eksempel. Programmet og tilpasning til andre vektor plattformer og effekter av transgener vil akselerere utviklingen av romanen immunovirotherapeutics for klinisk oversettelse.

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Kreftforskning problemet 143 kan virotherapy kreft immunterapi viral vektorer meslinger viruset paramyxovirus bispecific T celle agere
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