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Nanoparticelle di ossido di ferro rivestite con Polyethyleneimine come un veicolo per la consegna di piccolo RNA interferente ai macrofagi In Vitro e In Vivo

Article DOI: 10.3791/58660-v • 09:36 min • February 5th, 2019
February 5th, 2019 •
*1, *2, 1, 1, 2, 2, 1
1Key Laboratory of Ministry of Education for Developmental Genes & Human Diseases, Institute of Life Sciences and School of Medicine, Southeast University, 2State Key Laboratory of Bioelectronics, Jiangsu Key Laboratory for Biomaterials & Devices, School of Biological Science & Medical Engineering, Southeast University
* These authors contributed equally

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Descriviamo un metodo di utilizzo polyethyleneimine (PEI)-rivestito di nanoparticelle di ossido di ferro superparamagnetico per macrofagi trasfezione con siRNA. Queste nanoparticelle è in grado di fornire in modo efficiente siRNA di espressione del gene bersaglio macrofagi in vitro e in vivo e silenzio.

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Medicina problema 144 macrofago trasfezione nanoparticelle consegna di siRNA polyethyleneimine veicolo silenziamento genico
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