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Journal / Chemistry / Pretargeted Radioimmunotherapy basert på Inverse…
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JoVE Journal Chemistry
Pretargeted Radioimmunotherapy basert på Inverse Electron etterspørsel Diels-Alderreaksjonen
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Pretargeted Radioimmunotherapy basert på Inverse Electron etterspørsel Diels-Alderreaksjonen

Article DOI: 10.3791/59041-v • 09:44 min • January 29th, 2019
January 29th, 2019 •
1,2, 1,2,3, 1,2,3,4
1Department of Chemistry, Hunter College of the City University of New York, 2Ph.D. Program in Chemistry, Graduate Center of the City University of New York, 3Department of Radiology, Memorial Sloan Kettering Cancer Center, 4Department of Radiology, Weill Cornell Medical College

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Denne protokollen beskriver syntese og karakterisering av en trans- cyclooctene (TCO)-endret antistoff og en 177Lu-merket tetrazine (Tz) radioligand for pretargeted radioimmunotherapy (PRIT). I tillegg detaljer det bruken av disse to konstruerer for i vivo biodistribution og langsgående terapi studier i en murine modell av tykktarmskreft.

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Kjemi problemet 143 radioimmunotherapy pretargeted radioimmunotherapy pretargeting omvendt elektron etterspørsel Diels-Alder reaksjon tetrazine trans- cyclooctene huA33 A33 antigen lutetium-177
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