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Pretargeted Radioimmunotherapy ters elektron talep Diels-Alder reaksiyonu üzerinde dayalı
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Pretargeted Radioimmunotherapy ters elektron talep Diels-Alder reaksiyonu üzerinde dayalı

Article DOI: 10.3791/59041-v • 09:44 min • January 29th, 2019
January 29th, 2019 •
1,2, 1,2,3, 1,2,3,4
1Department of Chemistry, Hunter College of the City University of New York, 2Ph.D. Program in Chemistry, Graduate Center of the City University of New York, 3Department of Radiology, Memorial Sloan Kettering Cancer Center, 4Department of Radiology, Weill Cornell Medical College

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Sentez ve karakterizasyonu bir trans- cyclooctene (TCO) bu protokolünü açıklar-modifiye antikor ve 177Lu etiketli tetrazine (Tz) radioligand pretargeted radioimmunotherapy (PRIT) için. Buna ek olarak, bu iki yapıları kullanımı vivo içinde biodistribution ve boyuna terapi çalışmaları kolorektal kanser, bir fare modeli için ayrıntıları.

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Kimya sayı 143 radioimmunotherapy pretargeted radioimmunotherapy pretargeting ters elektron talep Diels-Alder reaksiyonu tetrazine trans- cyclooctene huA33 A33 antijen Lutesyum-177
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