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Synthese und Biokonjugaten der Thiol-reaktive Reagenzien für die Erstellung der Website selektiv geändert Immunokonjugate
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Synthesis of Cyclic Polymers and Characterization of Their Diffusive Motion in the Melt State at the Single Molecule Level
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Synthese und Biokonjugaten der Thiol-reaktive Reagenzien für die Erstellung der Website selektiv geändert Immunokonjugate

Article DOI: 10.3791/59063-v • 08:47 min • March 6th, 2019
March 6th, 2019 •
1, 1,2, 1, 1,2,3,4
1Department of Chemistry, Hunter College of the City University of New York, 2Ph.D. Program in Chemistry, Graduate Center of the City University of New York, 3Department of Radiology, Memorial Sloan Kettering Cancer Center, 4Department of Radiology, Weill Cornell Medical College

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In diesem Protokoll wird die Synthese von Hülsen, ein Phenyoxadiazolyl Methyl Sulfon-basierte Reagenz für die Website-selektive Befestigung der Ladungen an die Thiole von Biomolekülen, insbesondere Antikörper beschrieben. Darüber hinaus beschreiben wir die Synthese und Charakterisierung von eine Hülsen tragenden bifunktionelle Chelator und die Konjugation zu einem Modell-Antikörper.

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Chemie Ausgabe 145 standortspezifische Biokonjugaten Website-selektive Biokonjugaten Maleimide Thiol Sulfhydryl Radioimmunoconjugate immunoconjugate
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