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Efficace Construction d’échafaudages Drug-like Bispirocyclic Via Cycloadditions rapide de α-Imino γ-Lactones et alkylidène Hydantoïdes
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Efficace Construction d’échafaudages Drug-like Bispirocyclic Via Cycloadditions rapide de α-Imino γ-Lactones et alkylidène Hydantoïdes

Article DOI: 10.3791/59155-v • 10:17 min • February 7th, 2019
February 7th, 2019 •
1, 2, 2, 2
1School of Basic Medical Sciences, Lanzhou University, 2School of Pharmaceutical Sciences, Sun Yat-sen University

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Bispiro énantiomériquement enrichi [γ-butyrolactone-pyrrolidine-4, 4'-pyrazolone] squelettes sont asymétriquement synthétisés par une réaction de cycloaddition 1, 3-dipolaire simple rapide.

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Chimie numéro 144 synthèse asymétrique Organocatalyse bispirocyclic composés cycloaddition lactones hydantoïdes
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