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Immunology and Infection

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JoVE Journal Immunology and Infection
Un dispositif de positionnement pour le placement des souris pendant la livraison de siRNA intranasal au système nerveux central
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Un dispositif de positionnement pour le placement des souris pendant la livraison de siRNA intranasal au système nerveux central

Article DOI: 10.3791/59201-v • 05:28 min • August 15th, 2019
August 15th, 2019 •
1,2, 1, 2, 1, 2
1Department of Bioengineering and Institute of Nanoscience and Technology, Hanyang University, 2Department of Internal Medicine, Section of Infectious Diseases, Yale University School of Medicine

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Ici, nous présentons un protocole utilisant un dispositif de positionnement de souris qui permet le placement approprié des souris pour l'administration intranasale d'une formulation de peptide-siRNA de cerveau-ciblage permettant le silençage efficace de gène dans le système nerveux central.

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Immunologie et infection numéro 150 administration intranasale livraison du cerveau siRNA peptide RVG9R dispositif de positionnement de la souris nez-à-cerveau
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