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JoVE Journal Cancer Research
Forutsi i Vivo Payloads levering med en blod-hjerne svulst barriere i en rett
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Forutsi i Vivo Payloads levering med en blod-hjerne svulst barriere i en rett

Article DOI: 10.3791/59384-v • 13:34 min • April 16th, 2019
April 16th, 2019 •
1, 1,2, 1,3
1Research Programs Unit, Translational Cancer Medicine Research Program, University of Helsinki, 2Wihuri Research Institute, Biomedicum Helsinki, University of Helsinki, 3Laboratory Animal Center, Helsinki Institute of Life Science (HiLIFE), University of Helsinki

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Stoffet målretting til sentralnervesystemet svulster er en stor utfordring. Her beskriver vi en protokoll for å produsere en i vitro etterligne av blod-hjerne svulst-barrieren bruke murine og/eller menneskelige celler og diskutere deres relevans for forutsigbarheten av sentralnervesystemet svulst målretting i vivo.

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Kreftforskning problemet 146 blod-hjerne svulst barriere glioblastom intercellulære transport i vivo bildebehandling nanopartikler endothelial permeabilitet CooP peptid svulst målretting co kulturer astrocyttene endothelial celledifferensiering
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