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Syntese, Functionalization og karakterisering af Fusogenic porøs silicium nanopartikler til oligonukleotid levering

Article DOI: 10.3791/59440-v • 08:53 min • April 16th, 2019
April 16th, 2019 •
1, 1,2
1Materials Science and Engineering Program, University of California, San Diego, 2Department of Chemistry and Biochemistry, University of California, San Diego

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Vi demonstrere syntesen af fusogenic porøs silicium nanopartikler til effektiv in vitro- og in vivo oligonukleotid levering. Porøs silicium nanopartikler er lastet med siRNA til kernen, som er belagt med fusogenic lipider gennem ekstrudering at danne skallen. Målretning gruppe functionalization og partikel karakterisering er inkluderet.

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Engineering drug spørgsmålet 146 porøs silicium Nanomedicin delivery genterapi siRNA syntese nanopartikel Liposom fusion oligonukleotid knockdown
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