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Direkte Intrabronchial administration til at forbedre den selektive agens deposition i mus lunge
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Direkte Intrabronchial administration til at forbedre den selektive agens deposition i mus lunge

Article DOI: 10.3791/59450-v • 07:10 min • May 20th, 2019
May 20th, 2019 •
1, 1, 1,2, 1
1Department of Medicine, University of Colorado Denver, 2Department of Medicine, Denver Health Medical Center

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Intratracheal (IT) administration af eksperimentelle agenter i mus resulterer ofte i asymmetrisk levering til de distale lunger.  I denne rapport beskriver vi en direkte intrabronchial (IB) tilgang til at cannulere hver lunge i levende mus ikke-operativt.  Denne fremgangsmåde kan bruges til selektivt at administrere agenter til en lunge eller kan tilpasses til at forbedre den symmetriske middel levering til begge lunger.

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Medicin Intratracheal instillation intrabronchial instillation lungefibrose bleomycin mus lungeskade
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