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Journal / Immunology and Infection / 非酒精性脂肪性肝炎合并2型糖尿病的一种先进的小鼠模型…
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Immunology and Infection

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JoVE Journal Immunology and Infection
非酒精性脂肪性肝炎合并2型糖尿病的一种先进的小鼠模型
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非酒精性脂肪性肝炎合并2型糖尿病的一种先进的小鼠模型

Article DOI: 10.3791/59470-v • 10:17 min • April 26th, 2019
April 26th, 2019 •
1,2,3,4, 3,6, 3,5, 3,5, *1,2,4, *2,3,5
1Department of Endocrinology & Metabolism Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, 2Berlin Institute of Health (BIH), 3Berlin-Brandenburg Center for Regenerative Therapies (BCRT), Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, 4DZHK (German Centre for Cardiovascular Research), 5Institute of Medical Immunology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, 6Julius Wolff Institute (JWI) and Center for Musculoskeletal Surgery, Charité - Universitätsmedizin Berlin, Berlin, Germany, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin
* These authors contributed equally

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描述了一种简单可靠的饮食诱导的非酒精性脂肪性肝炎 (NASH) 啮齿类动物模型, 通过动物的非 spf 外壳和特定高脂肪饮食的管理实现。我们描述了肝脏和脂肪免疫细胞亚群的鉴定, 通过使小鼠接触环境细菌来重述人类的免疫状况。

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免疫学与感染 第146期 免疫学和环境暴露、肥胖、适应性免疫学、胰岛素抵抗、住房条件、代谢表型、流式细胞术
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