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Immunology and Infection

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JoVE Journal Immunology and Infection
En avansert murine modell for alkoholfrie steatohepatitis i samarbeid med type 2 diabetes
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En avansert murine modell for alkoholfrie steatohepatitis i samarbeid med type 2 diabetes

Article DOI: 10.3791/59470-v • 10:17 min • April 26th, 2019
April 26th, 2019 •
1,2,3,4, 3,6, 3,5, 3,5, *1,2,4, *2,3,5
1Department of Endocrinology & Metabolism Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, 2Berlin Institute of Health (BIH), 3Berlin-Brandenburg Center for Regenerative Therapies (BCRT), Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, 4DZHK (German Centre for Cardiovascular Research), 5Institute of Medical Immunology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, 6Julius Wolff Institute (JWI) and Center for Musculoskeletal Surgery, Charité - Universitätsmedizin Berlin, Berlin, Germany, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin
* These authors contributed equally

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En enkel og pålitelig diett-indusert gnager dyr modell for alkoholfrie steatohepatitis (NASH) er beskrevet, oppnås gjennom ikke-SPF boliger av dyrene og administrasjon av en bestemt høy-fett diett. Vi beskriver identifisering av lever-og fett immunceller undergrupper for å recapitulate menneskelige immunologiske tilstander ved å utsette mus for miljø bakterier.

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Immunologi og infeksjon immunologi og miljømessige eksponering fedme adaptive immunologi insulinresistens bolig forhold metabolsk bestemmelse av fenotype flyt flowcytometri
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