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Kemisk inaktivering af E3 Ubiquitin Ligase Cereblon ved Pomalidomid-baserede homo-PROTACs
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Kemisk inaktivering af E3 Ubiquitin Ligase Cereblon ved Pomalidomid-baserede homo-PROTACs

Article DOI: 10.3791/59472-v • 10:44 min • May 15th, 2019
May 15th, 2019 •
*1, *2, 1, 2, 2, 1
1Department of Internal Medicine III, University Hospital Ulm, 2Pharmaceutical Institute, Pharmaceutical Chemistry I, University of Bonn
* These authors contributed equally

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Dette arbejde beskriver syntesen og karakteriseringen af en pomalidomid-baseret, bifunktionel homo-PROTAC som en ny metode til at fremkalde allestedsnærværende og nedbrydning af E3 ubiquitin ubiquitinligase cereblon (CRBN), målet for thalidomid analogerne.

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Kemi CRBN PROTAC IMiD pomalidomid ubiquitin Ligase myelomatose proteasom
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