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JoVE Journal Chemistry
Chemische Inaktivierung des E3 Ubiquitin Ligase Cereblon durch Pomalidomid-basierte Homo-PROTACs
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Chemische Inaktivierung des E3 Ubiquitin Ligase Cereblon durch Pomalidomid-basierte Homo-PROTACs

Article DOI: 10.3791/59472-v • 10:44 min • May 15th, 2019
May 15th, 2019 •
*1, *2, 1, 2, 2, 1
1Department of Internal Medicine III, University Hospital Ulm, 2Pharmaceutical Institute, Pharmaceutical Chemistry I, University of Bonn
* These authors contributed equally

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Diese Arbeit beschreibt die Synthese und Charakterisierung eines pomalidomidbasierten, bifunktionellen Homo-PROTAC als einen neuartigen Ansatz zur Induzieren von Ubiquitination und Abbau des E3 Ubiquitin Ligase Cereblon (CRBN), dem Ziel von Thalidomid-Analogen.

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Chemie Ausgabe 147 CRBN PROTAC IMiD Pomalidomid Ubiquitinligase Multiples Myelom Proteasom
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