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Journal / Neuroscience / Comprehensive Autopsy Program for Individuals…
JoVE Journal
Neuroscience

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JoVE Journal Neuroscience
Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
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Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

Article DOI: 10.3791/59511-v • 09:41 min • July 19th, 2019
July 19th, 2019 •
*1, *1,3, *3, *2, 1, 1, 1, 1, 1, 3, 1
1Department of Neurosciences, Lerner Research Institute, Cleveland Clinic, 2Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, 3Mellen Center for Treatment and Research in Multiple Sclerosis, Neurological Institute, Cleveland Clinic
* These authors contributed equally

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Summary
Automatic Translation

Multiple sclerosis is an inflammatory demyelinating disease with no cure. Analysis of brain tissue provides important clues to understanding the pathogenesis of the disease. Here we discuss the methodology and downstream analysis of MS brain tissue collected through a unique rapid autopsy program in operation at the Cleveland Clinic.

Tags

Autopsy Program Multiple Sclerosis Pathogenesis Rapid Autopsy Brain Study Molecular Studies In Situ MRI Pathological Changes Brain Imaging Tissue Processing RNA Analysis Immunostaining Immunoblotting MRI Correlations Post Mortem Fixation Times Tissue Integrity MRI Analysis Experts
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