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Journal / Bioengineering / Organóides neurais humanos para estudar câncer…
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Bioengineering

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JoVE Journal Bioengineering
Organóides neurais humanos para estudar câncer cerebral e doenças neurodegenerativas
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Organóides neurais humanos para estudar câncer cerebral e doenças neurodegenerativas

Article DOI: 10.3791/59682-v • 09:36 min • June 28th, 2019
June 28th, 2019 •
*1, *2, 2, 3, 3, 4, 5, 4, 2
1Laboratory of Tumor Immunology, Translational Research Center in Onco-Hematology, Department of Internal Medicine Specialties, Faculty of Medicine, University of Geneva, 2Department of Pathology and Immunology, University Medical Center, University of Geneva, 3Laboratory of Toxicology and Therapeutic Drug Monitoring, Geneva University Hospitals, 4Tissue Engineering Laboratory, Hepia/HES-SO, University of Applied Sciences Western Switzerland, 5Laboratory of Experimental cell therapy, Department of Diagnostics, Geneva University Hospitals
* These authors contributed equally

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Este estudo introduz e descreve protocolos para derivar dois organóides neurais humanos específicos como um modelo relevante e exato para estudar 1) desenvolvimento humano do glioblastoma dentro dos organóides neural humanos exclusivamente nos seres humanos e 2) neurônio dopaminérgicos diferenciação, gerando um organoide tridimensional.

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Bioengenharia edição 148 organóide neural glioblastoma multiforme células-tronco cancerosas células-tronco embrionárias humanas neurônios dopaminérgicos doença neurodegenerativa
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